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| Demarchi,Izabel Galhardo; Cardozo,Daniela Maira; Aristides,Sandra Mara Alessi; Moliterno,Ricardo Alberto; Silveira,Thaís Gomes Verzignassi; Cardoso,Rosilene Fressatti; Bertolini,Dennis Armando; Svidzinski,Terezinha Inez Estivalet; Teixeira,Jorge Juarez Vieira; Lonardoni,Maria Valdrinez Campana. |
| Highly active antiretroviral therapy (HAART) is used in patients infected with HIV. This treatment has been shown to significantly decrease opportunist infections such as those caused by viruses, fungi and particularly, protozoa. The use of HAART in HIV-positive persons is associated with immune reconstitution as well as decreased prevalence of oral candidiasis and candidal carriage. Antiretroviral therapy benefits patients who are co-infected by the human immunodeficiency virus (HIV), human herpes virus 8 (HHV-8), Epstein-Barr virus, hepatitis B virus (HBV), parvovirus B19 and cytomegalovirus (CMV). HAART has also led to a significant reduction in the incidence, and the modification of characteristics, of bacteremia by etiological agents such as... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Highly active antiretroviral therapy; Antiretroviral drugs/activity; Opportunist infections/treatment. |
| Ano: 2012 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502012000100019 |
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| Vanni,T.; Morejón,K.M.; Santana,R.C.; Melo,L. de; Ferrão,S.B.R.L.; Amorim,A.P.; Gaspar,G.G.; Ponzi,C.C.; Golin,N.A.; Custódio,F.L.; Marangoni,A.T.D.; Campos Jr.,C.P.; Fonseca,B.A.L.. |
| Since there are some concerns about the effectiveness of highly active antiretroviral therapy in developing countries, we compared the initial combination antiretroviral therapy with zidovudine and lamivudine plus either nelfinavir or efavirenz at a university-based outpatient service in Brazil. This was a retrospective comparative cohort study carried out in a tertiary level hospital. A total of 194 patients receiving either nelfinavir or efavirenz were identified through our electronic database search, but only 126 patients met the inclusion criteria. Patients were included if they were older than 18 years old, naive for antiretroviral therapy, and had at least 1 follow-up visit after starting the antiretroviral regimen. Fifty-one of the included... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: AIDS; HIV; Antiretroviral treatment; Efavirenz; Nelfinavir; Highly active antiretroviral therapy. |
| Ano: 2007 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007000700011 |
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| Vidal,José Ernesto; Song,Alice Tung Wan; Matos,Maria Laura; Bartmann,Daniel; Anjos,Guilherme dos; Miranda,Érique José Peixoto de; Freitas,Ângela Carvalho; Dalben,Mirian de Freitas; Santana,Claudinei; Segurado,Aluísio Cotrim; Barreto,Cláudia Cortese; Hernández,Adrián Vladimir. |
| OBJECTIVES: To assess the virologic and immunological response of darunavir/ritonavir plus optimized background therapy in highly antiretroviral-experienced HIV-infected patients in Brazil. METHODS: Prospective cohort study carried out in a tertiary center in Sao Paulo, Brazil. Three-class antiretroviral-experienced patients with confirmed virologic failure began darunavir/ritonavir plus optimized background therapy (nucleoside/tide reverse transcriptase inhibitors ± raltegravir ± enfuvirtide ± maraviroc) after performing a genotypic resistance assay. Clinical evaluation and laboratory tests were collected at baseline and at weeks 12, 24, and 48. Multivariate analysis was performed to identify predictors of virologic response at 48 weeks. RESULTS:... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Highly active antiretroviral therapy; Darunavir; Acquired immunodeficiency syndrome; Developing countries. |
| Ano: 2013 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000100007 |
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| Ono,E.; Santos,A.M. Nunes dos; Succi,R.C. de Menezes; Machado,D.M.; Angelis,D.S.A. de; Salomão,R.; Kallás,E.G.; Moraes-Pinto,M.I. de. |
| The immune consequences of in utero HIV exposure to uninfected children whose mothers were submitted to highly active antiretroviral therapy (HAART) during gestation are not well defined. We evaluated 45 HIV-exposed uninfected (ENI) neonates and 45 healthy unexposed control (CT) neonates. All HIV-infected mothers received HAART during pregnancy, and the viral load at delivery was <50 copies/mL for 56.8%. Twenty-three ENI neonates were further evaluated after 12 months and compared to 23 unexposed healthy age-matched infants. Immunophenotyping was performed by flow cytometry in cord and peripheral blood. Cord blood lymphocyte numbers did not differ between groups. However, ENI neonates had a lower percentage of naive T cells than CT neonates (CD4+, 76.6... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Immunophenotyping; Highly active antiretroviral therapy; HIV-1; Immunological stimulation; Neonates of HIV-infected mothers. |
| Ano: 2008 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2008000800011 |
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| Pontes,L. C. R.; Carvalho,L. R.; Souza,L. R.; Trindade,E. B. S. M.; Pereira,P. C. M.. |
| Highly active antiretroviral therapy (HAART) has been associated with the development of a clinical group and metabolic disorders such as peripheral lipodystrophy syndrome in AIDS. The aim of this study was to analyze the lipid profile, the clinical aspects, and the body composition of HIV-1 infected individuals treated with or without protease inhibitor (PI) during the highly active antiretroviral therapy. In total, 62 individuals were evaluated in this study; 15 healthy individuals (Control Group: CG), 11 HIV-1 infected individuals treated without antiretroviral therapy (Group 1: G1), 14 HIV-1 infected individuals treated with antiretroviral therapy plus protease inhibitor (Group 2: G2), and 22 HIV-1 infected individuals treated with antiretroviral... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Lipodystrophy; HIV-1; Highly active antiretroviral therapy; Dyslipidemia; Hypertriglyceridemia. |
| Ano: 2005 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992005000200006 |
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| Betancur,Mónica Narváez; Lins,Liliane; Oliveira,Irismar Reis de; Brites,Carlos. |
| Abstract The introduction of highly active antiretroviral therapy marked a major gain in efficacy of HIV/AIDS treatment and a reduction in morbidity and mortality of the infected patients. However, high levels of adherence are required to obtain virologic suppression. In Brazil, the policy of free and universal access to antiretroviral therapy has been in place since 1996, although there are reports of poor adherence. Objective To define the clinical, demographic and psychological characteristics, and quality of life of patients with HIV/AIDS who present poor adherence to highly active antiretroviral therapy. Methods This was a cross-sectional study. To be included in the study patients had to be 18 through 65 years old, diagnosed with HIV/AIDS, having... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Highly active antiretroviral therapy; HIV/AIDS; Adherence; Nonadherence; Anxiety; Depression; Quality of life. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000500507 |
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| Ernesto,Aline Santarem; Lemos,Renata Muller Banzato Pinto de; Huehara,Maria Ivone; Morcillo,André Moreno; Vilela,Maria Marluce dos Santos; Silva,Marcos Tadeu Nolasco da. |
| INTRODUCTION: Adherence, which is crucial to the success of antiretroviral therapy (HAART), is currently a major challenge in the care of children and adolescents living with HIV/AIDS. OBJECTIVE: To evaluate the prevalence of nonadherence to HAART using complementary instruments in a cohort of children and adolescents with HIV/AIDS followed in a reference service in Campinas, Brazil. METHODS: The level of adherence of 108 patients and caregivers was evaluated by an adapted standardized questionnaire and pharmacy dispensing records (PDR). Non-adherence was defined as a drug intake lower than 95% (on 24-hour or seven-day questionnaires), or as an interval of 38 days or more for pharmacy refills. The association between adherence and clinical, immunological,... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Acquired immunodeficiency; Syndrome; Child; Adolescent; Highly active antiretroviral therapy; Medication adherence. |
| Ano: 2012 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000400001 |
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| Registros recuperados: 10 | |
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